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  • Gene therapy improved through vector modification

11th June 2008

Gene therapy improved through vector modification

Adeno-associated virus (AVV) has been identified as an attractive candidate for delivering gene therapy because it is able to infect cells without causing disease. Studies show that a certain vector DNA modification has drastically improved the efficiency for reaching the nucleus. This type of genetically altered AVV could reduce the amount of vector (payload virus) needed for treatment and save significant research dollars through improved effectiveness.

Two weeks after the mice were injected with the corrective gene, one of the new AAV-gene combos was working 29 times better than the standard vector was at incorporating the new gene into cells, at a 10-fold lower dose.

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9th June 2008

Real Time PCR in 17 minutes

Real time PCR is responsible for the majority of DNA and RNA sequencing in clinical laboratories.  This technique is used in paternity tests, forensics,  and virology.  The future of real time PCR just became smaller and more efficient.

...the researchers were able to isolate 30 cells implanted with the genetic information for a green-fluorescing protein from 25 µL of blood, concentrate them 100-fold, wash them, rupture them, and detect the gene for the green protein by real-time PCR—all within just 17 minutes!

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posted in Automation, Bio Technology | 0 Comments