Gene therapy improved through vector modification
Adeno-associated virus (AVV) has been identified as an attractive candidate for delivering gene therapy because it is able to infect cells without causing disease. Studies show that a certain vector DNA modification has drastically improved the efficiency for reaching the nucleus. This type of genetically altered AVV could reduce the amount of vector (payload virus) needed for treatment and save significant research dollars through improved effectiveness.
Two weeks after the mice were injected with the corrective gene, one of the new AAV-gene combos was working 29 times better than the standard vector was at incorporating the new gene into cells, at a 10-fold lower dose.
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