11th
June
2008
Gene therapy improved through vector modification
posted in Bio Technology |
Adeno-associated virus (AVV) has been identified as an attractive candidate for delivering gene therapy because it is able to infect cells without causing disease. Studies show that a certain vector DNA modification has drastically improved the efficiency for reaching the nucleus. This type of genetically altered AVV could reduce the amount of vector (payload virus) needed for treatment and save significant research dollars through improved effectiveness.
Two weeks after the mice were injected with the corrective gene, one of the new AAV-gene combos was working 29 times better than the standard vector was at incorporating the new gene into cells, at a 10-fold lower dose.
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on Wednesday, June 11th, 2008 at 4:05 pm and is filed under Bio Technology.
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